2D cellular model
Monitoring of the vitality of cellular models is the key toward human-relevant and reproducible toxicity testing.
Toxic effects of mercury are detected through changes in the extracellular acidification of fibroblasts. Cellular recovery is seen after the toxin is removed.
Cellular model: 3T3 fibroblasts as 2D monolayer.
3D cellular model
With the automated fluidic system in vivo-like situations can be mapped to the in vitro experiments.
Extracellular acidification rate is used to assess toxicity of 1% sodium dodecyl sulfate solution on HepG2 liver spheroids.
Cellular model: HepG2 hepatocellular carcinoma based 3D spheroids.