2D cellular model

Monitoring of the vitality of cellular models is the key toward human-relevant and reproducible toxicity testing.

Toxic effects of mercury are detected through changes in the extracellular acidification of fibroblasts. Cellular recovery is seen after the toxin is removed.

Cellular model:  3T3 fibroblasts as 2D monolayer.

3D cellular model

With the automated fluidic system in vivo-like situations can be mapped to the in vitro experiments.

Extracellular acidification rate is used to assess toxicity of 1% sodium dodecyl sulfate solution on HepG2 liver spheroids.

Cellular model:  HepG2 hepatocellular carcinoma based 3D spheroids.